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Management- PINK

Goals of care

  • Maintain oxygenation and perfusion
  • Promote oxygenation and perfusion
  • Prevent Hypoxia
  • Risk of Hypoxia
  • Improve Respiratory Function and Oxygenation/ Perfusion

Oxygenation & Perfusion are essential for organ function and overall health. Monitoring is critical for preventing complications from decreased oxygen delivery and for preventing complications from decreased cardiac output. Insufficient oxygen levels can occur due to poor breathing and or ventilation. Oxygen demands will increase with stress. Managing fluid status helps prevent complications such as hypovolemia or dehydration. Critical for preventing complications from decreased cardiac output and ensuring adequate oxygen delivery. Insufficient oxygen levels can occur if the infant due to poor breathing and or ventilation. Hypoxia can impair glucose metabolism, leading to hypoglycaemia, which in turn leads to further hypoxia. Oxygen demands will increase with stress.

Strategies

Maintaining oxygenation and perfusion in premature and hemodynamically unstable infants in the Special Care Nursery is a critical component of neonatal care. These infants are vulnerable due to either immature organ systems or poor physiologic reserves. Strategies must be individualised and based on continuous assessment. Strategies include respiratory support (supplemental oxygen, high- flow nasal cannula (HFNC), Continuous Positive Airway Pressure (CPAP) and in the more unstable infant requiring NICU management mechanical ventilation and surfactant replacement therapy). Monitoring of oxygenation is essential via Pulse Oximetry and or Blood gas analysis with careful titration of any supplemental oxygen to avoid oxygen toxicity and or retinopathy of prematurity (ROP). And lastly positioning to optimise lung expansion

Interventions

Interventions include respiratory support (supplemental oxygen, high- flow nasal cannula (HFNC), Continuous Positive Airway Pressure (CPAP) and in the more unstable infant requiring NICU management mechanical ventilation and surfactant replacement therapy). Another essential component is monitoring of oxygenation via Pulse Oximetry and or Blood gas analysis with careful titration of any supplemental oxygen to avoid oxygen toxicity and or retinopathy of prematurity (ROP). Fluid management also needs to be targeted at the individual and continuously adjusted based on the infant’s evolving clinical condition.  And lastly positioning of the infant to optimise lung expansion

Maintain clear/patent airway: provide oxygen and or respiratory support to compromised infant.

Respiratory assessment: primary survey: look, listen & feel

Positioning: maintain clear airway (suction prn), initially consider prone position optimises lung expansion by decreasing the pressure of the diaphragm pushing up on the lungs, therefore enabling improved ventilation to the lungs

Incubator: enables visualisation of work of breathing & colour, infant is nursed naked in NTE

Monitor Perfusion Indicators: Check skin colour, capillary refill time less than 3 seconds, and peripheral pulses (strong or weak), signs of poor perfusion such as mottling, pallor.

Monitoring: On admission heart rate, respiratory rate, blood pressure, oxygen saturation and temperature then continuous monitoring of vital signs, to evaluate perfusion status, documented hourly or as directed by medical team.

Oxygen Monitoring: Continuously assess oxygen saturation levels and provide supplemental oxygen to maintain target levels (90-95% for preterm infants). Sats probe to be repositioned with cares 4-6 hourly to prevent pressure areas and or burns. (Oxygen saturation/ pulse oximetry and cardiorespiratory monitoring is a non-invasive means of obtaining immediate information on the infant’s O2 status). Blood gas (capillary or arterial).

Supplemental oxygen and or Respiratory Support: various options and will be on the guidance of a medical practitioner, ranging from supplementary oxygen in incubator, to non-invasive options (e.g., CPAP, high-flow nasal cannula) or invasive ventilation as needed for respiratory support, with protocols for weaning off as the infant stabilises.

Test & Procedures Chest X-Ray, septic workup

Intravenous therapy (IVT): Ensure proper hydration and adjust fluid intake based on clinical needs and laboratory results. (U &E’s, maintain Fluid balance chart)

BP monitoring & Correcting hypovolemia is essential as a stable cardiovascular status will assist in the recovery of respiratory distress.by improving gaseous exchange. Maintenance of the circulation cannot be over emphasised. The result of a reduction in circulating blood volume can cause pre-renal renal failure unless aggressive management is adopted. Volume replacement with blood of Fresh Frozen Plasma (FFP), saline or albumin is indicated. Blood & FFP are most beneficial as they theoretically not only replace volume but also contain immunoglobulins & clotting factors.  Saline is effective in treating hypotension as is albumin.  If volume replacement is insufficient to treat hypotension, inotropes may be commenced.

Haematological Management: Careful running of the total of blood taken for tests need to be recorded as sick infants tolerate anaemia badly.

Regular Skin Assessments: Perform with cares/nappy changes (4-6 hourly) to identify any signs of skin breakdown, rashes, or infections.

Evaluation

Improving condition, skin well perfused, brisk capillary refill,

    • Improvement in SpO₂ (maintained >90% on minimal O₂ support).
    • Improvement in SpO₂ (>95%) in room air, reduced respiratory distress, normal blood gas levels
    • Reduction in respiratory distress signs (decreased grunting, nasal flaring, retractions).
    • Stable respiratory rate within normal range (40-60 breaths per minute).
    • Improved blood gas results (PaO₂ within normal range, resolving respiratory acidosis).

Documentation: Record the infant’s temperature 4 hourly unless deviated from norm, then intervention required and reevaluate in one hour, note any deviations from normal and escalate accordingly

Treating the Underlying Cause- Depending on the cause of respiratory distress (e.g., prematurity (surfactant deficiency) infectionpneumoniameconium aspirationcongenital anomalies, etc.), specific treatments such as antibioticsinotropes, or surgical intervention may be required

Complications of inadequate oxygenation:

– Hypoxia,

– anaerobic glycolysis,

– hypocarbia,

– cell and organ damage.

 

Complications of too much oxygen

– Retinopathy of prematurity (ROP)

– Oxygen toxicity

Managing oxygenation & perfusion in some more commonly seen SCN presentations

*** this is a guide only: always refer to local policy and or guidelines to ensure you are practicing within hospital frameworks and your scope of practice***

Hypothermia

Cold stress causes an increases oxygen and glucose consumption as the infant tries to generate heat which can lead to worsening hypoxia & hypoglycaemia 

Aim to maintaining normothermia (temperature between 36.5- 37.5-degree Celsius)

Hypoglycaemia 

Hypoglycaemia may occur due to increased metabolic demands thus regular BSL monitoring. BSL 4-6 hours

Signs of Poor Perfusion: Be vigilant for clinical signs of poor perfusion, such as lethargy, hypotonia, or feeding difficulties, which may indicate severe hypoglycaemia or other complications.

Respiratory Distress

Oxygen demands increase with stress– depending on underlying cause, respirations can be compromised due to abdominal distention which may invoke diaphragmatic splinting, resulting in poor oxygenation & CO2 retention. Possibility of ventilatory support to correct respiratory acidaemia. Treatment of metabolic acidosis with sodium bicarbonate may be indicative with a septic infant.

Arterial/capillary blood gas analysis: essential if hypoxemia: if responding to supplemental O2 suspect that respiratory failure secondary to alveolar hypoventilation. Careful with O2 administration, aim to provide adequate tissue oxygenation without oxygen toxicity.

Correcting hypovolemia via BP monitoring is essential as a stable cardiovascular status will assist in the recovery of respiratory distress.

Radiology- chest Xray to rule out lung disease

Prone position if not contraindicated (contraindications include un-monitored infant, umbilical lines) Rationale: prone position optimises lung expansion by decreasing the pressure of the diaphragm pushing up on the lungs, therefore enabling improved ventilation, therefore improving lung efficiency by getting oxygen.

Apnoea of Prematurity (APO)management- Caffeine Citrate is administered either via intravenous infusion or orally with a loading dose followed by a maintenance dose. Monitoring of heart rate, number and severity of apnoea episodes and assess for agitation. Consider withholding dose if Heart rate is greater than 180 bpm. Cardiorespiratory monitoring should continue for at least 5-7 days after the cessation of caffeine treatment for apnoea

Prematurity

Premature neonates often have underdeveloped cardiovascular and respiratory systems, making perfusion and oxygenation management critical

Respiratory support/supplementary oxygen: Oxygen support is often necessary, either through nasal cannulas, continuous positive airway pressure (CPAP), or mechanical ventilation, depending on the severity of respiratory distress.

Monitoring: Regular monitoring of oxygen saturation levels (SpO2) is essential to prevent hypoxia or hyperoxia, which can lead to complications like retinopathy of prematurity (ROP).

Intravenous Access: Maintaining IV access is crucial for administering fluids, medications, and nutrition.

Blood Pressure Monitoring: Monitoring blood pressure to assess perfusion and treat conditions like hypotension, which can lead to organ damage.

Cardiovascular Support: Medications such as inotropes may be used to support cardiac function if needed.

Hyperbilirubinemia

While oxygenation is not always directly impacted by neonatal jaundice, it is important to monitor the infant’s perfusion and oxygenation.

Measure Serum Bilirubin (SBR): Regularly monitor serum bilirubin levels (as per local guideline) to gauge the effectiveness of the phototherapy and guide adjustments. Rationale: Regular SBR measurements ensure the treatment’s effectiveness and safety.

Monitoring- Full cardiovascular monitoring and or pulse oximetry (HR RR, SATS Temp). Sats probe to be repositioned with cares 4-6 hourly

Monitor Perfusion Indicators: Check skin colour, capillary refill time <3, and +-peripheral pulses.

Manage Fluids: Ensure proper hydration and adjust fluid intake based on clinical needs and laboratory results. (U &E’s, maintain Fluid balance chart)

If nursing infant in prone position, consider below:

Monitor Respiratory Status: Assess for any signs of respiratory distress,

Pulse Oximetry: Monitor oxygen saturation levels with pulse oximetry, particularly for preterm infants or those with underlying respiratory concerns.

Feeding Intolerance

Cardio-respiratory Monitoring: Oxygenation is critical in maintaining the neonate’s overall stability and improving feeding tolerance. Inadequate oxygenation can impair gastrointestinal function and exacerbate feeding intolerance

Suspected Sepsis

Acid Base Balance may be compromised in septic shock.

Cardiovascular Support: Septic infant is likely to be shocked as assessment & management of Blood Pressure & perfusion are of paramount importance. Peripheral perfusion & capillary refill time needs to be frequently measured.  BP maintained within normal limits.  Both are often compromised due to poor cardiac output, acidemia & low circulating volume.

Strict Fluid Balance: of the hemodynamically unstable infant includes both input and urine output being measured, this can be achieved by weighing nappies, urine collection bags or catheterisation.

Abdominal Xray (AXR) if feeding intolerance evident to rule out NEC

Septic screen – Blood culture, Full blood examination and urea/creatine levels as well as C-reactive protein (CRP),

Investigations done on the infant with suspected infection require definitive results, but these can take 12-24 hours to return, so blood tests such as C-reactive protein (CRP), can be highly predictive to diagnose infection but not 100% yet will only take an hour or so to return a result.

Blood cultures– ideal before starting treatment with AB’s and is considered which are positive are the definitive result of sepsis in a suspected infant

Treatment for suspected infection varies in different units, usually driven by common pathogens in the community. Nevertheless, treatment consists of broad range antibiotics to cover both gram positive and gram-negative organisms. Antibiotic therapy (first line benzyl penicillin and gentamicin) until blood culture returns approximately 48 hours

Neonatal Abstinence Syndrome (NAS)

Respiratory: Infants with NAS may have respiratory symptoms such as tachypnoea, nasal congestion, and irritability, which can lead to difficulty with oxygenation- management of symptomatic infants is always done in consultation with medical team

 

References

Gardner, S., Carter, B., Enzman-Hines, M. and Niermeyer, S. (2021) Merenstein and Gardner’s Handbook of Neonatal Intensive Care. 9th Edition. Elsevier.  

Kain, V., and Mannix, T. (2023). Neonatal Care for Nurses and Midwives. Principles for Practice. Second edition. Elsevier.

Safer Care Victoria (2018). Respiratory Distress Syndrome (RDS) in neonates. Safer Care Victoria https://www.safercare.vic.gov.au/best-practice-improvement/clinical-guidance/neonatal/respiratory-distress-syndrome-rds-in-neonates  (accessed November 2024)

 

 

 

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Neonatal Care Essentials for Nursing and Midwifery Copyright © 2025 by Deakin University is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.